TECHNICAL SUPPLEMENT · CHAPTER 19

The Blockade

Name: Thirteen Points Wide | The Dopamine Brain, Chapter 19
Uploaded: 2026-09-18T07:54:10-07:00
Duration: 9 min 2 s
Description: There is exactly one place in medicine where we have measured, in living people, how much of a receptor a drug must fill to work and how much filling starts to hurt. The gap is thirteen percentage points. I will show you what sits inside it, what these drugs actually cost the person taking them, and why anyone who tells you the long-term question is settled is telling you about themselves.

There is exactly one place in medicine where we have measured, in living people, how much of a receptor a drug must fill to work and how much filling starts to hurt. The gap is thirteen percentage points. I will show you what sits inside it, what these drugs actually cost the person taking them, and why anyone who tells you the long-term question is settled is telling you about themselves.

12 pages · 18 references, every one verified · written by Dr. Gurpreet Singh Padda, MD, MBA, MHP

Watch Chapter 19

The chapter on video — the same argument, with the figures and the studies on screen as they come up.

The receipts behind Chapter 19

The book makes the argument. This supplement shows the evidence, claim by claim: the study, who was in it, the number and where it sits in the paper, what it does not show — and the questions to bring to your own physician. It is written to be shared with your doctor.

Enter your name, email and mobile number. The Chapter 19 PDF arrives by email within a few minutes, and the other thirty supplements arrive one a week, in order. We do not send marketing texts; your number is there so we can reply if you ask us something.

Educational material, not medical advice. If you are in the St. Louis area and want this looked at properly, that is what the Addictionology Center is for.