TECHNICAL SUPPLEMENT · CHAPTER 25

The Anti-Reward Hub

Name: The Brain Structure That Says No | The Dopamine Brain, Chapter 25
Uploaded: 2026-09-18T08:04:28-07:00
Duration: 8 min 48 s
Description: Two structures the size of a grain of rice sit behind your thalamus, and their whole job is to switch dopamine off. I think this is the most exciting mechanism in the book, which is exactly why I give it the hardest scrutiny in the book. Here is the brake, the evidence for it, and everything about it that still does not add up.

Two structures the size of a grain of rice sit behind your thalamus, and their whole job is to switch dopamine off. I think this is the most exciting mechanism in the book, which is exactly why I give it the hardest scrutiny in the book. Here is the brake, the evidence for it, and everything about it that still does not add up.

13 pages · 19 references, every one verified · written by Dr. Gurpreet Singh Padda, MD, MBA, MHP

Watch Chapter 25

The chapter on video — the same argument, with the figures and the studies on screen as they come up.

The receipts behind Chapter 25

The book makes the argument. This supplement shows the evidence, claim by claim: the study, who was in it, the number and where it sits in the paper, what it does not show — and the questions to bring to your own physician. It is written to be shared with your doctor.

Enter your name, email and mobile number. The Chapter 25 PDF arrives by email within a few minutes, and the other thirty supplements arrive one a week, in order. We do not send marketing texts; your number is there so we can reply if you ask us something.

Educational material, not medical advice. If you are in the St. Louis area and want this looked at properly, that is what the Addictionology Center is for.